Cognitive Remediation and Neuroimaging Laboratory
Laboratory
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The Cognitive Remediation and Neuroimaging Lab conducts innovative research with aims to better understand and treat cognitive difficulties in mental health disorders, such as depression and schizophrenia. We use brain imaging techniques to better understand brain correlates of neurocognitive and social cognitive impairments in various mental health disorders, as well as in youth at risk of developing these disorders. We are also interested in using digital technologies, such as smartphones and virtual reality, to develop better cognitive assessment tools and treatments to ultimately improve quality of life in individuals with mental health disorders.
Research Interests
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Cognitive impairments in mental health disorders
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Brain imaging
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Neurocognition
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Social cognition
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Cognitive remediation
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Cognitive assessment
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Digital technologies
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Virtual reality
Significant Work
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Saint-Georges, Z., MacDonald, J., Al-Khalili, R., Hamati, R., Solmi, M., Keshavan, M. S., Tuominen, L., & Guimond, S. (2025). Cholinergic system in schizophrenia: A systematic review and meta-analysis. Molecular Psychiatry, 30(7), 3301–3315. https://doi.org/10.1038/s41380-025-03023-y​
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Shannon, H., Bush, K., Shvetz, C., Paquin, V., Morency, J., Hellemans, K. G., & Guimond, S. (2024). Longitudinal Problematic Social Media Use in Students and Its Association with Negative Mental Health Outcomes. Psychology Research and Behavior Management, 17, 1551–1560. https://doi.org/10.2147/PRBM.S450217
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Shannon, H., Montgomery, M., Guimond, S., & Hellemans, K. (2025). Problematic social media use and inhibitory control among post-secondary students. Addictive Behaviors, 165, 108307. https://doi.org/10.1016/j.addbeh.2025.108307
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Yee, J., Matheson, H., Bogie, B. J. M., Perron, É. D., Thérond, A., Charest, M., Driel, C. van, Goyette, M., Lei, Y. T., Noël, C., Ariaratnam, K., Collins, G., Gorman, C., Cretu, A.-M., Tremblay, S., Rivard, M.-C., Cullwick, C., Morris, C., Attwood, D. G., … Guimond, S. (2025). Cognitive Remediation for Psychosis in Virtual Reality (ThinkTactic VR): Qualitative, Iterative, and User-Centered Codevelopment Study. JMIR Mental Health, 12(1), e69359. https://doi.org/10.2196/69359
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Bogie, B. J. M., Noël, C., Gu, F., Nadeau, S., Shvetz, C., Khan, H., Rivard, M.-C., Bouchard, S., Lepage, M., & Guimond, S. (2024). Using virtual reality to improve verbal episodic memory in schizophrenia: A proof-of-concept trial. Schizophrenia Research: Cognition, 36, 100305. https://doi.org/10.1016/j.scog.2024.100305
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Pezzoli, P., Therond, A., Nikolic, M., Watts, S. K., Guimond, S., & Seto, M. C. (2024). Reducing antisocial behavior through cognitive training: A systematic review and meta-analysis. Aggression and Violent Behavior, 79, 102006. https://doi.org/10.1016/j.avb.2024.102006
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Tucci, A. A., Schroeder, A., Noël, C., Shvetz, C., Yee, J., Howard, A. L., Keshavan, M. S., & Guimond, S. (2023). Social cognition in youth with a first-degree relative with schizophrenia: A systematic scoping review. Psychiatry Research, 323, 115173. https://doi.org/10.1016/j.psychres.2023.115173
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Paquin, V., Philippe, F. L., Shannon, H.*, Guimond, S., Ouellet-Morin, I., & Geoffroy, M. (pre-print). Associations between digital media use and psychotic experiences in young adults of Quebec, Canada: a longitudinal study.
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Al-Haddad, R., Chamoun, M., Tardif, C.L., Guimond, S., Horga, G., Rosa-Neto, P., Cassidy., C.M. (2022). Normative values of neuromelanin-sensitive MRI signal in older adults obtained using a standard protocol for acquisition and analysis. Journal of Magnetic Resonance Imaging.
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Hansen, J., Shafiei, G., Markello, R., Smart, K., Cox, S., Wu, Y., Gallezot, J. -D., Aumont, E., Servaes, S., Scala, S., DuBois, J., Wainstein, G., Bezgin, G., Funck, T., Schmitz, T., Spreng, R. N., Soucy, J. -P., Baillet, S., Guimond, S., … Misic, B (2022). Mapping neurotransmitter systems to the structural and functional organization of the human neocortex. ​
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Guimond, S., Sarvode, S., Makowski, C., Chakravarty, M., & Keshavan, M. (2022). Altered Age-Related Subcortical Trajectories in Familial High Risk of Schizophrenia with Transition to Psychosis. Translational Psychiatry, 12, 202
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Shannon, H., Bush, K., Villeneuve, P., Hellemans, K., Guimond, S. (2022). Problematic social media use in adolescents and young adults: Systematic review and meta-analysis. JMIR Mental Health.
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Schroeder, A., Bogie, B. J. M., Rahman, T., Thérond, A., Matheson, H., & Guimond, S. (2022). Feasibility and efficacy of virtual reality interventions to improve psychosocial functioning in psychosis: A systematic review. JMIR Mental Health, 9(2), e28502.
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Lavigne, K , Sauvé, G, Raucher-Chéné, D, Guimond, S, Lecomte, T., Bowie, C., Menon, M., Lal, S., & Lepage, M. (2022). Remote cognitive assessment in severe mental illness: A scoping review. npj Schizophrenia, 8.
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Guimond, S., Ling, G., Drodge, J., Matheson, H., Wojtalik, J. A., Lopez, B., Collin G, Brady R, Mesholam-Gately RI, Thermenos H, Eack SM, Keshavan, M. S. (2022). Functional Connectivity Associated with Improvement in Emotion Management after Cognitive Enhancement Therapy in Early-Course Schizophrenia. Psychological Medicine. 52(12), 2245–2254. https://doi.org/10.1017/S0033291720004110
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Noël, C., Gu, F., Ormston, L., Tingue, S., Tucci, A., Pezzoli, P., Padani, S., Sandoval, L., Wojtalik, J., Eack, S., Keshavan, M., Guimond, S. (2021). Cognitive Enhancement Therapy in Early Schizophrenia: A Qualitative and Quantitative Case Series of Patients’ Experiences. Journal of Psychosocial Rehabilitation and Mental Health. 8(2), 109–123
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Guimond, S., Sandoval, L. R., & Keshavan, M. (2020) Schizophrenia, Book chapter in Chiaravalloti N., & Weber E., Cognitive Rehabilitation: Examining the Evidence from Brain to Behavior, Springer Publishing Company.
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Guimond, S., Keshavan, M.S., Torous, J.B. (2019). Towards remote digital phenotyping of cognition in schizophrenia, Schizophrenia Research, 208, 36-38.
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Kelly, S.*, Guimond, S.*, Lyall, A., Stone, W. S., Shenton, M. E., Keshavan, M.S., & Seidman, L. J. (2019). Neural correlates of cognitive deficits across developmental phases of schizophrenia. Neurobiology of Disease.
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Guimond, S., Padani, S., Lutz, O., Eack, S., Thermenos, H., & Keshavan, M. (2018). Impaired regulation of emotional distractors during working memory load in schizophrenia. Journal of psychiatric research, 101, 14.
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Guimond, S., Béland, S., & Lepage, M. (2018). Strategy for Semantic Association Memory (SESAME) training: Effects on brain functioning in schizophrenia. Psychiatry Research: Neuroimaging, 271, 50-58.
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